The polyunsaturated fatty acid omega-3 is an important weapon in combating inflammation, the principal cause of stress-related illness. However, when it comes to helping lift depression, not all types of omega-3 fatty acids are equal. According to a study presented at the 49th Annual Meeting of the American College of Neuropsychopharmacology which took place Dec. 5-9 in Florida, only eicosapentaenoic acid (EPA) has been shown to produce significant mood improvement in patients with depression. The other type of omega-3 fatty acid, docosahexaenoic acid (DHA), has no effect on depression.
The two omega-3 fatty acids EPA and DHA are found together in food (primarily fish and nuts) in a 1:1 ratio, but man-made supplements contain either EPA or DHA or a combination of both, in a ratio that may favor one vs. the other and may vary by manufacturer. In order to take advantage of omega-3’s antidepressant effects, it is therefore important to choose supplements that have an EPA-predominant formulation.
Among the many Omega-3 supplements that are rich in EPA for antidepressant effects, some of the highest rated are NutraSea Herring Oil (with a 3:1 EPA to DHA ratio), AST Bioactive Omega-3 EPA Amino Hybrid (with a 5:1 EPA to DHA ratio), and Pharmax High EPA Fish Oil.